The Stars of the Show (Part III)

Part three of a seven-part series.  View parts one, two, four and five.

Necrophilia Explained, Or, Trust Your Perception’s Unifying Theory
of Standard Male Bullshit

THE STARS OF THE SHOW (PART III)

Individual scientists may have been aware of the Y chromosome’s problems as early as 1932, though a wider discussion didn’t start until the 1950s, when a hot topic in research papers was comparing mens’ Y size. But with the success of the Human Genome Project (1990-2005), and the sequencing of the Y chromosome, genetic research has gone full frenzy. Thousands of researchers world-wide are publishing papers on sex- , sex-chromosome- and reproduction-related topics. Many of these papers are free to read on Google Scholar. (But be prepared for your head to hurt for days, as scientists are loathe to name the agent, much less the problem. “Suboptimal levels of X-linked expression,” for example, is how to say/not say: “Y decrepitude is SO bad, not even the normal X dude gets from ma can save his ass.” Though Trust is in agreement with the female researcher quoted here on dudes’ suboptimal levels of expression). While the research teams and scientific journal editorial boards still tilt male, many many women are taking part in this race — yet patriarchal mind prevails.

A handful of geneticists have stepped forward to dutifully report mens’ demise. Permit Trust to introduce some of the stars of this unfolding drama.

Dudes Are Doomed, the Docudrama, Starring:

Jennifer A. Marshall Graves, PhD, of Australia. A former Fulbright Scholar and world-renowned geneticist, Dr. Marshall Graves headed jg1the Comparative Genomics Research Unit at Australian National University. She is an expert on marsupials, as well as mammalian sex chromosomes. Dr. Marshall Graves was the first geneticist to suggest in a 2000 paper that the Y chromosome is declining and will inevitably disappear. (Graves’ work to date is written for other geneticists, so isn’t easily quoted here).

Bryan Sykes, PhD, of the UK. One of the world’s leading geneticists. Dr. Sykes is Professor of Genetics at the 5fe0fdaa32c10ad8986cff.L._V192575469_SX200_Institute of Molecular Medicine at Oxford University. He is also Science Adviser to the British Parliament. Dr. Sykes was the first to map the lineage of Womankind through mitochondrial DNA, back to our original African mother, “Mitochondrial Eve.” Sykes focuses on the 7 mothers of Europe in his book, The Seven Daughters of Eve. Dr. Sykes was also the first to take the subject of men’s inevitable demise to the general public in Adam’s Curse: A Future Without Men. For his efforts, Dr. Sykes receives hate mail regularly.

Jones200Steve Jones, PhD, of Wales. Dr. Jones was professor of biology and genetics at University College, London. He appears regularly on BBC Radio and writes a science column for “The Daily Telegraph.” Dr. Jones is the author of Y: The Descent of Men, which “updates” Darwin’s subtitle, (The Origin of the Species:) The Descent of Man.

David Page, PhD, of the US. Director of the Whitehead Institute, affiliated with The Massachusetts Institute of Technology (MIT). Dr. Pagedavid-page1 was responsible for sequencing the Y chromosome (predictably, the actual work, tedious beyond-human-patience, was done by two women on his team: Tomoko Kuroda-Kawaguchi and Helen Skaletsky). Page has publicly stated repeatedly, and even while pursuing grant money from the US government: “I’ve spent the better part of my career, thankfully with the (financial) support of the National Institute of Health and the National Genome Research Institute for the past 21 years, defending the honor of the Y chromosome in the face of innumerable insults to its character and its future prospects.” (bold and emphasis, Trust’s) Page and research assistant Jennifer Handmaiden Hughes have recently made news by arguing that the Y isn’t dying. Ms. Hughes has appeared in the scientific and general media on behalf of the Whitehead Institute, arguing that the Y is stable, healthy, and ingenious. Page and his team focus on the Y.

Nettie Stevens, PhD (1861-1912), of the US. One of the first geneticists. Dr. Stevens discovered the XX female-sex-chromosomes and the Y-male-sex chromosome. She was the first to realize chromosomes existed in pairs, and are different in males and females. With her NettieStevenschromosomal theory of inheritance, Dr. Stevens’ work put an end to Aristotle’s 2,000-year-old unintentionally-hilarious dudeponder that dudeheat (said to be exceptional) makes babyboys. (Dr. Stevens’ work was stolen and commandeered, ala Rosalind Franklin, who discovered DNA and lost the Noble Prize to public schoolboys Crick and Watson, who literally crept into Franklin’s office when she wasn’t there, and lifted her work, and Mileva Maric, Einstein’s first wife, who lost her shared ideas and the Noble Prize to ex-husband Albert, world’s most famous Dudegenius, who then left her by the roadside). Thomas Hunt Morgan has regularly been given credit for Dr. Stevens’ discoveries. Hemorgan_thomas was awarded the Noble Prize after appropriating Dr. Stevens’ work, — which he initially dismissed. Morgan used Stevens’ work to improve on Gregor Mendel’s work through studying fruit flies — fruit flies Stevens brought him. (Fruit flies and rodents are “studied” by scientists because they mirror male (and female) – sex chromosomes). When Dr. Nettie Stevens died of breast cancer in 1912 at the age of 51, only 9 years after economically-struggling and otherwise overcoming manblocks to earn her PhD, having published 38 scientific papers in 11 years, Thomas Hunt Morgan dismissed her in an obituary he wrote for the journal Science, declaring Dr. Nettie Stevens not even a scientist.

Jennifer A. Marshall Graves was the first to state the obvious. In 2000, she published a paper in the scientific journal Biology and Reproduction titled, amazingly: “Human Y Chromosome, Sex Determination and Spermatogenisis – A Feminist View,” in which she stated: “…I wish to argue that, far from being a macho entity with an all-powerful role in male development, the human ‘Y’ chromosome is a ‘wimp… (The ‘Y’ chromosome) is merely a relic of the X chromosome.” Ultimately the evidence shows, Graves concludes, that: “The wimpy Y chromosome is disappearing fast…” Disrespectfully trashing centuries of Dudegenius, Graves then (be)mused: “Perhaps then, it is time to reassess the adage that maleness is dominant, and femaleness (an understudy) condition. The view of females as some sort of deficient, mutant males (is wrong)… the genetic element that defines maleness – that is the mutant element.”

Graves’ piece was not noticed much, until she rewrote it with a new lead (ie, Sperm are Dying! Dying-Sperm Linked to Dying Y!), her name now appearing after “R. John Aitken” in the journal Nature (The Future of Sex. Vol 415, 28 February, 2002. p 963). This time Graves got the scientific world’s, um, – attention.

David Page, who still calls humans “man,” gets laffs every time with the same line recounting the impact of Graves’ article in his public speeches: “A grad student came rushing into my office with the Nature article, tears streaming down his face. — We held an emergency lab meeting and resolved to pick up the pace of our research.” Page, weirdly, never mentions the article’s authors by name, though refers to the Nature article in public speeches as “an editorial.” The dudeaudience – rimshot – laffs.

In 2003, Bryan Sykes summarized the research on the Y chromosome in Adam’s Curse: A Future Without Men, bravely intended for a general audience. The same year, Steve Jones published Y: The Descent of Man.

Trust Your Perceptions will step aside for Sykes and Jones, who, in their own words, explain the State of Man:

On maleness:

“…(T)he human template is female. Men are genetically-modified women.” (Sykes on ABC)

“Freud’s antique notion of women as diminished men is quite wrong. Biology reveals instead every man’s battle to escape the woman within.” (Jones)

“Maleness…was a mutation….We can tell this because there are still a few genes on the human Y-chromosome which have recognizable counterparts on the X-chromosome… pointing to a distant common ancestry.” (Sykes)

“Sex is an extremely inefficient way of reproducing yourself, simply because the production of males is cripplingly wasteful.” (Sykes)

“(Sex) is a truly enormous burden which falls primarily on females who have to spend half their time and effort producing essentially useless males…” (Sykes)

“Males are, in the genetical sense, parasites upon females.” “(Men) use female flesh to copy their own DNA.” “Males are, in many ways, parasites upon their partners. Their interests are to persuade the other party to invest in reproduction, while doing as little as they can themselves. Like all vermin, from viruses to tapeworms, they force their reluctant landladies to adapt or to be overwhelmed. As the host evolves to cope with her unwelcome visitor, the two parties enter a biological dance. Each has its own agenda, and as one gains, the other fights back…Whenever a new illness emerges or an old ailment flares up, those under attack must respond or die. The parasite, whatever it may be, constantly tests it’s hosts fortifications with new mechanisms of virulence – which in turn are fended off. Neither party can afford to relax, and little by little a complex and rickety structure of defense and counterattack evolves…” (Jones)

On the Y chromosome:

“Research on the Y-chromosomes (ran longer than expected because) all Y-chromosomes seemed to be exactly the same.” “After many years of late nights in the lab and sequence after sequence of frustrating uniformity, enough differences were found to enable researchers to begin sorting out the spectrum of Y-chromosome variation.” “…(I)t had been far more difficult than anyone had predicted to find genetic variations in Y-chromosomes.” (Sykes)

“(The Y-chromosome) is filled with parasites, redundancy and decay. The chromosome unique to men is a microcosmic metaphor of those who bear it…” (Jones)

“The Y-chromosome itself is a graveyard of genes…” “One by one, (the Y’s)…useful genes were lost until now only 27 remain – and they are under constant threat.” (Sykes)

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“Once a chromosome has been denied the opportunity to recombine with its partner this limits its capacity to repair the damage inflicted by mutation. Sexual recombination has a healing effect, allowing damaged genes to be resuscitated by their healthy companions on the undamaged chromosome during the “final embrace” before they go their separate ways… Chromosomes denied this nursing care get sicker and sicker. Mutations, almost all of which are inevitably harmful, silence genes one after another…” “Without any capacity for repair, the mutations keep on accumulating.” (Sykes)

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“To make matters worse, the Y-chromosome is hit by mutations more than any other chromosome. The reason for this extra insult is that the Y-chromosomes must spend their entire lives, for generations after generation, in the…testis.” “And cells in the testis never stop dividing. To keep up with the massive daily output of sperm…they are never allowed to rest.” “… (It’s a) hothouse atmosphere…” “…(These are) hostile conditions…” “Not only do the male (sperm) cells have to keep dividing day and night to keep up the supply of sperm, (but toxins are produced in making the tail of sperm. The more sperm, the more toxins).” “A toxic environment coupled with rapid cell division makes the male germline cell a very DNA-unfriendly place indeed.” (Sykes)

“(Additionally)…When mutations hit vital genes, they cause genetic diseases, and these damaging changes are ten to fifteen times more likely to happen in (men, who then introduce them into the species).” (Sykes)

“But not all mutations are quite so drastic in their effects. They can wound a gene without killing it outright. The wounded Y-chromosome, just a little bit less healthy than before, probably will get through. Then, a few generations later, another mutation will sting again. Not fatally, but enough to weaken it a little bit more. This is death by a thousand cuts. Unable to make long-term repairs themselves through sexual recombination, and isolated from external help, the wounded Y-chromosomes will stagger on through succeeding generations, gradually becoming weaker and weaker. One by one they will succumb to the effects of the final mutations that render the men who carry them completely sterile and only then will they disappear.” (Sykes)

“Even the ultimate master switch, the SRY gene itself…has been pounded… The SRY genes are changing far more quickly than their counterparts on the other chromosomes, and that alone shows the long-term effect of living in the ultra-hostile environment of the testis. However, only the SRY mutations with minimal effect can survive at all. If a mutation did cripple the SRY gene so that it could no longer switch on the path to male development, any embryo that did develop would be female. This is exactly what is found in XY females. They all have a Y-chromosome, but because the SRY gene didn’t work when it should have, the embryos developed into girls. Sequencing through the SRY genes of XY females, the damage becomes clear. The gene has been blasted and the mutations have hit vital parts of the instructions.” (Sykes)

“It is a race against time. Can a species get the genes it needs off the Y-chromosomes, or recreate them elsewhere, before it goes under? Always the last gene to go will by the SRY,

the master switch itself. We know it is capable of jumping ship and smuggling itself onto another chromosome. The evidence for this abandonment lies in the few cases of XX males… SRY can’t be located on the Y-chromosome – because they don’t have one. The SRY genes are stowed away on another chromosome. In the germline cells of their fathers, SRY became detached from the Y-chromosome and re-implanted somewhere else. However, iimagesn its hurry to leave the Y-chromosome…SRY has left the other genes behind. The few remaining genes on the Y-chromosome are still necessary for proper sperm production, so the XX men are, sadly, sterile.” “If these few genes had already left the Y-chromosome, or had their functions been reproduced elsewhere, the XX men would have been completely fertile and the species would be saved. Everything needed to make a man would then have escaped the doomed Y-chromosome and it could have been left to rot.” (Sykes)

“We are in the midst of an ascent of women matched with an equivalent descent of men.” (Jones)

Women-in-cafdan-Moroccan-Wedding

On sperm and infertility:

“Sperm are in a bad way these days.” “Low sperm counts were found in men in places as far apart as Peru, India, Libya and Nigeria.” “Low sperm counts are a major factor in male infertility. This is serious.” (Sykes)

“In 1950 Americans known to be fertile because they already had a child had an average count of around 100 million sperm per mililitre. In 1974 came the shock. The numbers had dropped by half, and a mere one husband in twenty could reach the previous standard.” (Jones)

“A recent worldwide study of thousands of volunteers suggested a drop from over 100 million sperm per mililetre of semen in 1940 to just 66 million a half century later. At this rate, (men) will make no sperm at all by the end of the (21st) century, and the population crisis will be solved.” (Jones)

“Great numbers of our own sperm fail to mature, and about a third are abnormal… Some have a swollen head, or a tail unable to lash in the correct way… Why men are so feeble, nobody knows.“ (Jones)

semen-analysis

“Between a third and a half of human sperm is anatomically abnormal, adopting an array of weird shapes that prevent it from swimming in the right direction. Some people excuse these deformities as devices to outwit sperm from other men that might be after the same egg. I doubt this is true because in our closest primate cousins, the chimpanzees, whose sperm really do face a lot of competition from other males because female chimps are copulating right, left and centre, 100 percent of the sperm is in excellent shape. Our poor performance against other animals can be judged by the fact that men produce approximately the same number of fit sperm per day as do hamsters, only a fraction of our size.” (Sykes)
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“…(S)ome men with gaps in their Y-chromosomes do experience problems with fertility….when their sperm is examined at a fertility clinic, there is something obviously wrong with it. Either there are far fewer than normal, sometimes none at all, or the sperm are even more misshapen than usual, or they are very sluggish. These men have suffered because the chunk of DNA missing from their Y-chromosome…contains one or more sperm production genes.” (Sykes)

“These are fresh mutations which disabled a Y-chromosome (as infertility cannot be inherited from a fertile father)…” (Sykes)

“…(T)he continuous and cumulative decay of the Y-chromosome will progressively and inexorably reduce male fertility to the point where men do become extinct. I deliberately use “men” instead of our species…” (Sykes)

“Mutations are random events that happen when DNA is copied as cells divide. So by a straightforward numerical logic, the more cell division there is, the more mutations their DNA will experience.” (emphasis, Trust’s) (Sykes)

“Whatever insults it may suffer from the external world, a sperm’s main cause of damage comes from within, and is, alas, impossible to avoid. Men make their reproductive cells all the time, from puberty to death.” “The chances of a mistakes (increase) each time the DNA is copied.” “For (mens’) secretions damage (men).” (Jones)

“ …(T)he testis are held outside the body in order to cool them down by a couple of degrees. If (sperm) were kept at normal body temperature, sperm production would fail completely.” (emphasis, Trust’s) “In fact, so sensitive are they to temperature that warming the testicles has proven a very effective, and easily reversible, contraceptive.” “Bakers, welders, and furnace workers all suffer from high testicular temperature and low sperm counts, as do taxi-drivers and other men who spend all day sitting down without allowing a draught of cooling air to waft over their parts.” (Sykes)

“…(A)fter a couple hours behind the wheel the scrotum is two degrees warmer than after the same time on foot. All drivers suffer, and men who are wheelchair bound are at particular risk as their testis never get a chance to cool down… A sauna does the job even better (and it can take weeks to get back to normal). Even worse, baby boys who wear plastic-covered diapers are warmer below the waist than those in cotton. Diapers themselves go on for longer in the lax Western world… Boys whose testicles are hot because they do not descend from the body cavity tend to be infertile, and wearers of high-technology baby-wear may pay the penalty when they grow up. One treatment uses a fan directed at the male organs while their owner sleeps.” (Jones)

fanboy

In 2003, the same year Sykes and Jones published for the general public, Page and his team also announced they had finally succeeded, after 13 years, in sequencing the Y chromosome. Spinning from the get-go, “The Male-Specific Region of the Y-Chromosome is a Mosaic of Discrete Sequence Classes” (which sounds way-better than “We Finally Found A Way to Tell Dudes Apart,” or “Dudes Hardly Left”) appeared in the journal Nature.

Page reported that the Y chromosome, ingeniously, copied itself in an attempt to fix its own mutations. Unable to do mutual-relationship-type-recombination like all other chromosomes, the Y chromosome created 8 intensely redundant “palindromes,” — writing, for example, AM ADAM, MADAM, A, seemingly fucking endlessly — then bending themselves in half to try to get their dying-asses fixed. According to Page, “Indeed, nearly all of the >99.9% sequences (highly-redundant palindromes) exist as pairs in inverted orientation.” He called this “our discovery of abundant recombination.” Scientific journals reported Page’s team’s finding with headers such as:“The Y Chromosome: A Crystal Palace of Mirrors,” ad hilariousum. Generaldudewriters even wondered if all that freak-out activity on the Y qualified as evolution: “Are Men More Evolved than Women?” they asked.

In 2004, in an article titled, “The Degenerate Y Chromosome – Can Conversion Save It?” Graves responded to Page: “(The discovery of palindromes) will not lead to a drive towards a more functional Y. The forces of evolution have made the Y a genetically-isolated non-recombining entity, vulnerable to genetic drift and selection for favorable new variants sharing the Y with damaging mutations. Perhaps it will even speed up the decline of the Y…” (emphasis, Trust’s)

Sykes, in his 2004 American edition of Adam’s Curse, also responded to Page: “…(T)his kind of internal recombination is not without its dangers. There is no guarantee that the gene conversion will repair a damaged copy. The essential ignorance of the DNA makes it equally likely that the good copy will be spoiled instead. Also, the palindromes themselves are vulnerable to deletion by the very process of internal recombination… If this happens, entire chunks of Y-chromosomes will be lost, often taking vital genes with them… Deletions of this type are a common cause of male infertility.”

Sykes continued: “(Mens’) ability to recombine internally, deduced from the study of one man’s Y-chromosome, was totally unexpected. It is certainly recombination of a sort, but a far cry from the vivacious gatherings enjoyed by the other nuclear chromosomes…where there is a chance to change partners at every generation. In comparison to these full-blown sexual liaisons, this is a lonely shuffle where each gene dances with a mirror image of itself and engages in a bit of mutual grooming. There is no chance for new gene combinations to arise, no protection against the onslaught of parasites, no contact with the outside world. It remains to be seen whether this sad gavotte has slowed down the pace of decay, or accelerated it. The Y-chromosome is as lonely as ever, but now we know it talks to itself as it spirals towards oblivion.” (Sykes)

surnames3Sykes then warns Mankind that they are now “…put on notice.” He lays out mens’ options:

“We now know, thanks to David Page’s work, all the genes that are present (in the Y)… Even with today’s comparatively primitive genetic engineering technology, it would be comparatively easy to cut them out of the wreckage…and assemble them them together in a compact genetic package. Or they could be made from scratch, even with present-day DNA synthesis instruments. From there, it would be a relatively straightforward task to insert the package into another chromosome…”

If invading and occupying another chromosome doesn’t work, Sykes alternately suggests enslaving another chromosome’s genes: “One strategy is to recruit genes on other chromosomes to take on the job of male development. It might only take a small mutation to convert a gene on another chromosome so that it becomes capable of duplicating the job of one of the endangered Y-chromosome genes… But it is a very risky strategy, and failure to have a backup somewhere else…have driven many species to extinction.”

Of course, according to Sykes, should these desperate measures fail:Many people (sic) would rejoice at the extinction of men. Valerie Solanas was one.” (Sykes is a reader, but lives in too rarefied a tower (not to mention he’s a dude) to comprehend life on the other side of men; no comprehension as a girlchild who was raped by men, no comprehension as a woman, who, in order to eat, was raped by men, and not a clue on the link between. Sykes refers to Solanas’ writing as “venomous).”

Trust cannot judge whether this final suggestion by Sykes was written in earnest. — Or written to scare the shit out of dudes. But this is how Bryan Sykes concludes his book: “One final genetic solution that I offer for scrutiny is the most radical. That is to abandon men altogether… There are no sperm to do battle, no Y-chromosomes to enslave the feminine. The destructive spiral of greed and ambition fueled by sexual selection diminishes and, as a direct result, the sickness of our planet eases. The world no longer reverberates to the sound of men’s crashing antlers and the grim repercussions of private and public warfare. The great sexual experiment…is over. Mitochondria and the female have finally triumphed…and Gia can resume her…sleep.”

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In 2010-2011, Page resurfaced with Jennifer Handmaiden Hughes to tell the world the Y is not – Repeat: NOTDYING. This followed another Page article in Nature, but this time (ohsocleverly) headlined by Hughes. Page and Hughes appeared together and separately in

both the scientific and general media. Page made himself heard on The Colbert Report, NPR, and in The New York Times. The written-word media, which follows the lead of The New York Times, disseminated the article widely.

According to The New York Times article by staff science writer Nicholas Wade, who carries on the time-honored tradition of Male Reversal: “This DNA swapping process (recombination) is forbidden between the X and Y pair, keeping the male-determining gene from being transferred into the X-chromosome, creating gender chaos.” (Not that the Y chromosome can’t recombine because it’s decayed to the point that someone should be calling HOSPICE. No. The Y chromosome can’t recombine on purpose. Dude Integrity is like — maintained — through dude-exclusive space, cuz — special. It is SO NOT that we wouldn’t just die to get our limping asses onto an X-chromosome. And-how-are-we-suppose-to-know who’s been stealing your genetic shit? Why do you even leave that stuff laying around?)

The article continues: “A new look at the human Y-chromosome has overturned longstanding ideas about its evolutionary history. Far from being in a state of decay, the Y-chromosome is the fastest-changing part of the human genome and is constantly renewing itself.” “The hallmark of the Y-chromosome now turns out to be renewal and reinvigoration, once the unnecessary burden of…genes has been shed.” (We’re NOT on our deathbed. We’re at the gym, — Getting in shape. Lean and mean! We WANNA lose our genes. GENES SUCK).

And this thoughtful little dudegift from our science writer: “The Y-chromosome’s rapid rate of evolutionary change does not mean that men are evolving faster than women.” (Aw, a gentleman. And you didn’t even think there were any left. (Church is always a good place to look…))

Of course all this “information” came from Page, who then steps out from behind the curtain to say: “It is now clear that the Y-chromosome is by far the most rapidly evolving part of the human (genome).” So: “Evolving” is not synonymous with “Bombed.” On the contrary, Dr. Page: The Y chromosome, because of its inability to recombine, is by far the slowest part of the human genome to adapt to changing conditions – which is, duh – why it’s in its death throes. Also, “evolution,” biologically, means species-wide adaptation to changing environmental conditions which encourages survival, as in: “The extinction of males will catapult human evolution, as males had proved too costly.” Page, who fersure-fersure didn’t mean: ‘Y death, hallelujah, harbinger of the common good,’ misused “evolution” — spun it around – to introduce yet another Male Reversal to the world. The Y is NOT “evolving.” To be necro-Waitsian about it, the Y is “combing back his feathers as he feels the BLOOD in his shoe.”

Page has been clear: No amount of evidence will stand in the way of his defense of the Y chromosome. Obviously, science derived from and historically served white male world domination. But nowadayz, scientists the world over collect empirical evidence from which they draw conclusions. No scientist announces their preferred conclusions in lieu of empirical evidence. Because to do so makes you not a scientist, — but a propagandist.

page2_bannerPatriarchy’s little Himmler is working on making himself a public figure, the world-expert on the Y-chromosome, it’s spokesman, the guy-you-go-ask. Trust has noticed major media science writers sticking to Page. The Wikipedia entry on the Y chromosome also relies heavily on Pages’ work.

In 2011, Page, — appealing for funding from the National Genome Research Institute (NGRI), the US government agency which funded the Human Genome Project and continues to fund genetic research, — assured fellow-dudes that his life’s work has been to defend Y’shonor.” He then asked the NGRI for money to map the X and other non-sex chromosomes: “I will recommend we scrutinize about 160 of the most structurally-complex euychromatic sites on the human X and in autosomes by haploid iterative mapping and sequencing,” Page said. These structurally-complex sites, he added, “are crying-out for a little closer scrutiny.”…“There are about 160 sites that account for a disproportionate burden of disease…,” Page continued. “This investment will be returned a billion times.

It’s usually the start of something VERY BAD when white men start making maps. Page wants to better map the X and other chromosomes so he can figure out how and where to stick mens’ 45 dying-ass sperm-making genes, — or what? Sykes, after all, suggested that these genes be inserted into another chromosome. (The Director of the California Institute of Regenerative Medicine recently said, most creepily: “We might see a move towards artificial chromosomes and ‘genetic cassettes’ that can be inserted at the embryonic stage to correct for particular diseases…” Artificial chromosomes?? But who could need those?) David Page also impressed upon the men handing out money his desire for improved technology “for the naughty private parts of the genome…that we’re not even prepared to talk about entering yet.”

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Also in 2011, Graves and Hughes faced off at the 18th International Chromosome Conference in Manchester England to debate the the death of the Y chromosome. They headlined as: “THE GREAT DEBATE: Is the Y-Chromosome Disappearing?” The audience consisted of 300 sex-chromosome researchers — half women, half men.

In her introductory remarks, Graves assured the audience she was no “male-basher” and harbored no ulterior motive. (Has-one-dude-ever felt the need to open a debate this way?) Graves covered all research to date, and, (compared to jenny_gravesSykes’ 125,000 year estimate), was quite conservative in offering a 4.6 million year dude-expiration date. (Jones being much-too-generous in his 10 million years prediction). Graves gave these reasons why she thinks the Y is, as she said, “on its way out:” “Evidence that there is practically nothing left of the original human Y and the added part of the human Y is degrading rapidly.” “Evidence that the Y in other mammals undergoes lineage-specific degradation.” “Evidence that the Y has already gone nuts or completely disappeared in some rodent lineages.” “Evidence from right across the animal kingdom, and even plants, that Ys…degrade inexorably.” And that, because it can’t recombine, “The Y chromosome is subject to…inefficient selection.” So, NEAR DEAD, HAPPENING IN ALL Y MAMMALS (and other Y creatures and plants, with a few examples of having already happened). And CAN’T F*ING FIX ITSELF.

Jennifer Hughes
Jennifer Hughes

Hughs, on the other hand, pointed to the palindromes discovered by Page’s team. These, Hughs insisted, were the trick Y had up his sleeve – the brilliant way the Y counters its own decay: “The Y chromosome has shown it has ways to outsmart genetic decay in the absence of ‘normal’ recombination.” (Dudes tricky and smart. They are so, like, smart, laws of nature, can’t like, touch dudes. And what’s ‘normal’ anyways? Like what could be more normal than dudes?) The main argument from Hughs: “The Y hasn’t disappeared yet, and it’s been around for hundreds of millions of years.“ (DUDES STILL HERE! Plus: DUDES WERE HERE BEFORE!) (Trust will take on this-hundreds-of-million-of-years-of-dudedom idea in a future post: “The Chicken IS the Egg. Which Came First: The Chicken or the Rooster?) So, from Hughs: DUDES SMART, and like, DUDES FOREVER! (Hughs mustagot some dinner invites that night, — no?)

When the moderator asked the audience to vote on the persuasiveness of these two

geneticists’ arguments, the vote came back tied: All women voted for Graves, the men

unanimous for Handmaiden.

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In 2013, Page gave a talk on sex-differentiating medicine. (Which alert readers will note was an appeal Page used in asking for money to map the other chromosomes. Is Page really switching to male disease? Or creatively funding more Y research? Or is this self-proclaimed defender of the Y chromosome tying to acclimate people to the idea of sex-segregated ‘medical treatments?)’

Opening his talk, Dr. Page addressed the audience: “Across the course of time, scientists, no matter how brilliant they are, have gotten things wrong in a big way. For a long time, we thought the Earth was flat. And we thought that the Sun revolved around the Earth. Well, in this time of the Human Genome Revolution, it turns out that we are missing something of critical importance.” Page pauses. — Before launching into how medicine needs to be sex-differentiated.

What Page should have said next, in front of the banks of cameras, microphones and journalists of The World Media, is this:

“I am here to announce that scientists have been wrong in a big way again: We have been wrong about men and women. We have been wrong about men being the true human being, the important human being, the superior human being. When we learned the Earth was an orb revolving around the sun, contrary to how things seemed, our world-view was turned upside-down and we had to radically reconfigure our thinking. Now genetics has turned our world-view of men and women upside-down, and we have to radically reconfigure our thinking: Men are sperm accessories, who are in free fall to extinction. Women are the true human being, the important human being, the superior human being. Women are the center of the species. Women are what matters…”

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